"Destroy All Humans!" is an action-adventure game that originally released in 2005, developed by Pandemic Studios and published by THQ. The game is set in the 1950s and follows the story of Crypto, an alien from the Furon race, as he invades Earth with the mission to retrieve his DNA from captured clones. Players take control of Crypto, utilizing various advanced alien technologies, including a flying saucer armed with devastating weapons and a powerful psychic ability. The game is noted for its satirical portrayal of human society, with a strong emphasis on humor and parody of 1950s Americana.
Gameplay revolves around a combination of exploration, combat, and mission-based objectives. Players can engage in various activities such as abducting humans, demolishing buildings, and using mind-control abilities to manipulate the population. The open-world environment allows players to interact with the game world creatively, either by completing missions or causing chaos to undermine human defenses. With its retro-futuristic aesthetic and comedic tone, "Destroy All Humans!" provides a unique gaming experience that combines action, strategy, and humor, appealing to fans of both classic alien invasion narratives and action-packed gameplay. The game was well-received, leading to a remake released in 2020 that enhanced graphics and gameplay while maintaining the core feel of the original title.